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- W1-Professur „Biomedical Data Science“ der Medizinischen Fakultät der Martin-Luther-Universität Halle-Wittenberg [Details]
- Leiter der Core Unit „Bioinformatik, Datenintegration und – Analyse“ (CUBiDA) am UKER / FAU (2020 bis 2021)
- Promotion zum Dr. rer. biol. hum. (2019, summa cum laude)
- Master of Science (Medical Process Management) der Friedrich-Alexander-Universität Erlangen-Nürnberg (2015)
- Thema der Masterarbeit: „Prototypische Integration von Hochdurchsatzdaten („Omics“) mit klinischen Daten am UKER“
- Förderpreis GMDS für beste Abschlussarbeit im Bereich medizinische Informatik
- Master of Science (Bioinformatik) der Universität des Saarlandes (2009, mit Auszeichnung)
- Thema der Masterarbeit: „Analysis of membrane transporters focused on amino acid transporters and their pore region by threading and similarity search“
- Bachelor of Science (Computational Molecular Biology) der Universität des Saarlandes (2006)
- Thema der Bachelorarbeit: „geno2pheno[framework] – ein Software-Framework zur Gen-Annotation und Integration von sequenzbasierten Vorhersage-Modulen“ am Max-Planck-Institut für Informatik
- Metzger P., Hess M.E., Blaumeiser A., Pauli T., Schipperges V., Mertes R., Christoph J., Unberath P., Reimer N., Scheible R., Illert A.L., Busch H., Andrieux G., Boerries M.; 2023, MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making.Cancers, 15: 3456
- Moser K., Mikolajczyk R., Bauer A., Tiller D., Christoph J., Purschke O., Lückmann S.L., Frese T.; 2023, BeoNet-Halle-development of a multifunctional database for the automated extraction of healthcare data from general practitioner and specialist practices. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 66: 569-577.
- Renner C., Reimer N., Christoph J., Busch H., Metzger P., Boerries M., Ustjanzew A., Boehm D., Unberath P.; 2023, Extending cBioPortal for Therapy Recommendation Documentation in Molecular Tumor Boards: Development and Usability Study.
JMIR Medical Informatics, 11: e50017. - Schönharting W., Roehnisch T., Manoochehri M., Christoph J., Sieger M., Nogueira M., Martos-Contreras M.C., Kunz, 2023, Improved Survival of a HER2-Positive Metastatic Breast Cancer Patient Following a Personalized Peptide Immunization.
Vaccines, 11: 1023.
- Unberath P, Mahlmeister L, Reimer N, Busch H, Börries M, & Christoph J: Searching of Clinical Trials made easier in cBioPortal using Patients‘ Genetic and Clinical Profiles. Applied Clinical Informatics. 2022; (in press)
- Holzner D, Apfelbacher T, Wödle W, Schüttler C, Prokosch HU, Mikolajczyk R, Negash S, Kartschmit N, Manuilova I, Buch C, Gundlack J & Christoph J: Attitudes and Acceptance Towards Artificial Intelligence in Medical Care. Studies in Health Technology and Informatics 2022 (in review)
- Ustjanzew A, Desuki A, Ritzel C, Dolezilek AC, Wagner DC, Christoph J, … & Paret C. (2021): cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the Molecular Tumor Board. BMC medical informatics and decision making, 21(1), 1-13. DOI: 10.1186/s12911-021-01719-z. PMID: 34930224
- Reimer N, Unberath P, Busch H, Börries M, Metzger P, Ustjanzew A., … & Christoph, J: Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform. Studies in Health Technology and Informatics, 287, 139-143. DOI: 10.3233/SHTI210833. PMID: 34795098
- Gruendner J, Wolf N, Tögel L, Haller F, Prokosch HU, & Christoph J. (2020). Integrating Genomics and Clinical Data for Statistical Analysis by Using GEnome MINIng (GEMINI) and Fast Healthcare Interoperability Resources (FHIR): System Design and Implementation. Journal of Medical Internet Research, 22(10), e19879. PMID: 33026356
- Buechner P, Hinderer M, Unberath P, Metzger P, Boeker M, Acker T, Haller F, Mack E, Nowak D, Paret C, Schanze D, von Bubnoff N, Wagner S, Busch H, Boerries M, Christoph J. Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal. Diagnostics 2020, 10, 93. PMID: 32050609
- Unberath P, Prokosch HU, Gründner J, Erpenbeck M, Maier C, Christoph J. (2020). EHR-Independent Predictive Decision Support Architecture Based on OMOP. Applied Clinical Informatics, 11(03), 399-404. DOI: 10.1055/s-0040-1710393. PMID: 32492716
- Schnell A, Schwarz B, Wahlbuhl M, Allabauer I, Hess M, Weber S, Christoph J, … & Hoerning A. (2020). Distribution and Cytokine Profile of Peripheral B Cell Subsets Is Perturbed in Pediatric IBD and Partially Restored During a Successful IFX Therapy. Inflammatory Bowel Diseases. DOI: 10.1093/ibd/izaa054 PMID: 32185399
- Pugliese P, Knell C, Christoph J. Exchange of Clinical and Omics Data According to FAIR Principles: A Review of Open Source Solutions. Methods Inf Med. 2020;59(S 01):e13-e20. DOI:10.1055/s-0040-1712968 PMID: 32620018
- Kunz M, Wolf B, Fuchs M, Christoph J, Xiao K, Thum T, Atlan D, Prokosch HU, Thomas Dandekar. A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs. Briefings in Bioinformatics, 2019. DOI: 10.1093/bib/bbz066. PMID: 31578571
- Kunz M, Jeromin J, Fuchs M, Christoph J, Veronesi G, Flentje M, Nietzer S, Dandekar G, Dandekar T. In silico signaling modeling to understand cancer pathways and treatment responses. Briefings in Bioinformatics, 2019. DOI: 10.1093/bib/bbz033. PMID: 31117120
- Metzger P, Hess M, Jaravine V, Boeker M, Christoph J, Unberath P, … & Boerries M. (2019, January). Automated whole exome sequencing analysis pipeline to support a molecular tumor board. In ONCOLOGY RESEARCH AND TREATMENT (Vol. 42, pp. 59-59).
- Unberath P, Knell C, Prokosch HU, Christoph J. (2019). Developing New Analysis Functions for a Translational Research Platform: Extending the cBioPortal for Cancer Genomics. Studies in health technology and informatics, 258, 46-50. DOI: 10.3233/978-1-61499-959-1-46. PMID: 30942711
- Maier C, Christoph J, Schmidt D, Ganslandt T, Prokosch HU, Kraus S, Sedlmayr M. (2019). Experiences of Transforming a Complex Nephrologic Care and Research Database into i2b2 Using the IDRT Tools. Journal of healthcare engineering, 2019. DOI: 10.1155/2019/5640685. PMID: 30800257
- Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, …, Christoph J, …Boehmer L. (2019). β6‐integrin serves as a novel serum tumor marker for colorectal carcinoma. International journal of cancer. DOI: 10.1002/ijc.32137. PMID: 30653264
- Aghdassi A, Christoph A, Ribback S, Dombrowski F, Döring P, Barth C, Christoph J, Lerch M, Simon P: Gastrointestinal stromal tumors: clinical symptoms, location, metastasis formation and associated malignancies in a single center retrospective study. Digestive diseases (Basel, Switzerland) (2018): 1-9. DOI: 10.1159/000489556. PMID: 29870973
- Hinderer M, Boerries M, Boekers M, Neumaier M, Loubal FP, Acker T, Brunner M, Prokosch HU, Christoph J: Implementing Pharmacogenomic Clinical Decision Support into German Hospitals. Stud Health Technol Inform. 2018;247:870-874. DOI:10.3233/978-1-61499-852-5-870. PMID: 29678085
- Gründner J, Prokosch HU, Stürzl M, Croner R, Christoph J, Toddenroth D: Predicting clinical outcomes in colorectal cancer using machine learning. Stud Health Technol Inform. 2018 2018;247:101-105. DOI: 10.3233/978-1-61499-852-5-101. PMID: 29677931
- Christoph J, Knell C, Bosserhoff A, Naschberger E, Stürzl M, Rübner M, Seuss H, Ruh M, Prokosch HU, Sedlmayr B: Usability and Suitability of the omics-integrating analysis platform tranSMART for Translational Research and Education. Applied Clinical Informatics. 2017;8(4):1173-1183. DOI: 10.4338/ACI-2017-05-RA-0085. PMID: 29270954
- Christoph J, Knell C, Naschberger E, Stürzl M, Maier C, Prokosch HU, Sedlmayr M: Two Years of tranSMART in a University Hospital for Translational Research and Education. Stud Health Technol Inform. 2017;236:48-54. DOI: 10.3233/978-1-61499-759-7-70. PMID: 28508781
- Knell C, Sedlmayr M, Christoph J: Developing interactive plug-ins for for tranSMART using the SmartR framework workwork: The case of survival analysis. Stud Health Technol Inform. 2017;236:48-54. DOI: 10.3233/978-1-61499-759-7-375. PMID: 28508820
- Hinderer M, Boerries M, Haller F, Wagner S, Sollfranke S, Acker T, Prokosch HU, Christoph J: Supporting Molecular Tumor Boards in Molecular-guided Decision-making – the Current Status of Five German University Hospitals. Stud Health Technol Inform. 2017;236:48-54. DOI: 10.3233/978-1-61499-759-7-48. PMID: 28508778
- Seuss H, Dankerl P, Ihle M, Grandjean A, Hammon R, Kaestle N, Fasching P, Maier C, Christoph J, Sedlmayr M, Uder M, Cavallaro A, Hammon M: Semi-automated De-identification of German Content Sensitive Reports for Big Data Analytics. In RöFo-Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (Vol. 189, No. 07, pp. 661-671). © Georg Thieme Verlag KG. DOI: 10.1055/s-0043-102939. PMID: 28335044
- Sedlmayr M, Würfl T, Maier C, Häberle L, Fasching P, Prokosch HU, Christoph J: Optimizing R with SparkR on a commodity cluster for biomedical research. Computer Methods and Programs in Biomedicine, 137, 321-328. DOI: 10.1016/j.cmpb.2016.10.006. PMID: 28110735
- Löbe M, Ganslandt T, Lotzmann L, Mate S, Christoph J, Baum B, Sariyar M, Wu J, Stäubert S.: Simplified Deployment of Health Informatics Applications by Providing Docker Images. Studies in health technology and informatics, 228, 643. DOI: 10.3233/978-1-61499-678-1-643. PMID: 27577463
- Christoph J, Griebel L, Leb I, Engel I, Köpcke F, Toddenroth D, Prokosch HU, Laufer J, Marquardt K, Sedlmayr M: Secure Secondary Use of Clinical Data with Cloud-based NLP Services. Towards a Highly Scalable Research Infrastructure. Methods of information in medicine. 54.3 (2015): 276-282. DOI: 10.3414/ME13-01-0133. PMID: 25377309
- Griebel L, Prokosch HU, Köpcke F, Toddenroth D, Christoph J, Leb I, Engel I, Sedlmayr M: A scoping review of cloud computing in healthcare. BMC Medical Informatics and Decision Making 2015;15:17.DOI: 10.1186/s12911-015-0145-7. PMID: 25888747
- Christoph J, Maier C, Schmidt, M, Ganslandt T, Seldmayr M: Erschließung komplexer nephrologischer Daten – Erfahrungen bei der Transformation TBase nach i2b2. GMDS 2015. 60. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS). Krefeld, 06.-09.09.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. DOI: 10.3205/15gmds02
- Bauer C, Ganslandt T, Baum B, Christoph J, Engel I, Löbe M, Mate S, Stäubert S, Drepper J, Prokosch HU, Winter A, Saxu U: Integrated Data Repository Toolkit (IDRT) – A Suite of Programs to Facilitate Health Analytics on Heterogeneous Medical Data. Methods of Information in Medicine. 2015;54(6).DOI: 10.3414/ME15-01-0082. PMID: 26534843
- Wörner A, Christoph J, Mahler V: Typ-I-Allergien auf Vorratsmilben bei beruflich exponierten und nicht exponierten Patienten. Arbeitsmedizin – Sozialmedizin – Umweltmedizin 49.2014,11: 844-849.
- Leb I, Griebel L, Christoph J, Laufer J, Marquardt K, Prokosch HU, Toddenreoth D, Sedlmayr M: Datenschutzkonforme Sekundärnutzung strukturierter und freitextlicher Daten Mittels Cloud-Architektur, Tagungsband TELEMED 2013, S. 488 – 508.
- Griebel L, Leb I, Christoph J, Laufer J, Marquardt K, Prokosch HU, Toddenreoth D, Sedlmayr M: Cloud-Architektur für die datenschutzkonforme Sekundärnutzung struktrurierter und freitextlicher Daten, Proceedings of the eHealth2013. May 23-24; Vienna, Austria. OCG; 2013.
- Löbe M, Baum B, Christoph J, Drepper J, Ganslandt Th, Engel I, Mate S, Prokosch HU, Sax U, Stäubert S, Winter A: Integrated Repository Toolkit (IDRT) – Werkzeuge zum Betrieb klinischer Data Warehouses auf Basis von i2b2. MDI 2.2014: 48-48.
- Bock F, Matthaei M, Reinhard T, Böhringer D, Christoph J, Ganslandt T, Cursiefen C: High-dose subconjunctival cyclosporine a implants do not affect corneal neovascularization after high-risk keratoplasty. Ophthalmology. 2014 Sep;121(9):1677-82. DOI: 10.1016/j.ophtha.2014.03.016, PMID: 24780407
- Oberländer M, Linnebacher M, König A, Bogoevska V, Brodersen C, Kaatz R, Krohn M, Hackmann M, Ingenerf J, Christoph J, Mate S, Prokosch HU, Yekebas EF, Thorns C, Büning J, Prall F, Uhlig R, Roblick UJ, Izbicki JR, Klar E, Bruch HP, Vollmar B, Habermann JK: The ‚North German Tumor Bank of Colorectal Cancer‘: status report after the first 2 years of support by the German Cancer Aid Foundation. Langenbecks Arch. Surg. 398 (2013), S. 251-258. DOI: 10.1007/s00423-012-1043-4. PMID: 23292500
- Prokosch HU , Mate S, Christoph J, Beck A , Köpcke F, Stephan S, Beckmann MW , Rau T , Hartmann A , Wullich B , Breil B , Eckardt KU, Titze S , Habermann JK, Ingenerf J , Hackmann M , Ries M , Bürkle T, Ganslandt T: Designing and implementing a biobanking IT framework for multiple research scenarios. Stud Health Technol Inform 180 (2012), S. 559-563. DOI 10.3233/978-1-61499-101-4-559. PMID 22874253
- Ganslandt T, Sa U, Löbe M , Drepper J , Bauer C , Baum B , Christoph J, Mate S, Quade M, Stäubert S, Prokosch HU: Integrated Data Repository Toolkit: Werkzeuge zur Nachnutzung medizinischer Daten für die Forschung . Goltz U, Magnor MA, Appelrath HJ, Matthies H, Balke WT, Wolf LC (Hrsg.) : GI-Jahrestagung (Jahrestagung der Gesellschaft für Informatik, Braunschweig, Sep. 2012). 2012, S. 1252-1259.
