Program

Young Scientist Meeting

08:30 - 09:00
Early bird snack (for students, PhDs and Post-Docs only)

09:00 - 09:10
Welcome note
Ivonne Regel, Tony Gutschner, Jonas Rosendahl

09:10 - 11:15
Empowering the next researcher generation
Program designed by PhD students of RTG2751 in conjunction with German Pancreatic Cancer Research network
Session chairs: RTG2751/CRU325/CRU5002/CRC1321

09:10 - 09:30
Interactive Start - Icebreaker

09:30 – 10:20
Open Panel Discussion
Albrecht Neeße, Göttingen; Francisco X. Real, Madrid; Arina Wasner

10:20 – 10:35 Coffee break

10:35 - 11:15 
From despair to delight – publishing from the authors and editors’ perspective
Albrecht Neeße, Göttingen

11:15 - 12:00 Lunch bites

12:00
Welcome Note Main Conference
Jonas Rosendahl, Ivonne Regel, Tony Gutschner

Session 1: Early is the key – Biomarkers and therapeutic approaches in Pancreatic Cancer               
Chair Session 1: Patrick Michl, Heidelberg / Atul Verma, Halle (Saale)

12:10 - 12:35
Understanding the early events in PDAC development are key for a better treatment
Francisco X. Real, Madrid

12:35 - 12:50
Coxsackievirus B Infections as Drivers of Pancreatic Cancer Development
Peter Storz, Jacksonville

12:50 - 13:05
Obesity is shaping an immunosuppressive pancreatic microenvironment promoting PDAC in mice
Anne-Kristin Fritsche, Halle (Saale)

13:05 - 13:30
PDAC Precursor lesion – How to stratify the cancer risk
Irene Esposito, Düsseldorf

13:30 - 14:00 Coffee & Cake

Session 2: Current standards and novel treatment options in PDAC
Chair Session 2: Dieter Saur, Munich / Volker Ellenrieder, Göttingen

14:00 - 14:25
Current options for early pancreatic cancer detection in the clinic and beyond
Julia Mayerle, Munich

14:25 - 14:50
Surgery in PDAC – Still the most promising approach?
Michael Ghadimi, Göttingen

14:50 - 15:05
Vascular resections for PDAC: Pushing the boundaries
Ulrich Ronellenfitsch, Halle (Saale)

15:05 - 15:20
Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
Maj-Britt Paulsohn, Göttingen

15:20 - 15:45
How will we treat PDAC patient in 10 years?
Hana Algül, Munich

15:45 - 17:00
Poster-Session A (with Coffee & Cake)

17:15 - 18:00
Chair Keynote Lecture 1:
Thomas Gress, Marburg / Nehir Sahin, Göttingen

New biomarkers on the horizon (or why not)?
Nuria Malats, Madrid

18:30 Conference Get-Together (Leopoldina)

Session 3: Cellular heterogeneity in pancreatic cancer
Chair Session 3: Jörg Kleeff, Halle (Saale) / Joana Oschwald, Göttingen

08:00 - 08:25
Neutrophil-driven inflammation in PDAC progression
Dieter Saur, Munich

08:25 - 08:40
Context-specific role of SNAI2 in modulating lineage-specific 
transcription factor networks in PDAC
Akshay Kanakan, Stuttgart 

08:40 - 08:55
Exploring lineage plasticity in patient-derived in vitro and in vivo models of PDAC
Joana Oschwald, Göttingen 

08:55 - 09:20
Models to understand cell plasticity in PDAC development
Alexander Kleger, Ulm

09:20 - 09:45 
Novel insights into cancer-associated fibroblast heterogeneity 
Daniel Öhlund, Umea

09:45 - 10:50 Coffee break

Session 4: Novel models and approaches to study pancreatic cancer
Chair Session 4: Günter Schneider, Göttingen / Ilse Rooman, Brussels

10:50 - 11:15 
Modelling Tumor Cell States and Ecosystem Interactions in Pancreatic Cancer
Maximilian Reichert, Munich

11:15 - 11:30 
Mitogen-Induced Acinar Proliferation: Functional Equipotency and Oncogenic Selection
Jonathan Baldan, Brussels

11:30 - 11:45 
Precision-cut tissue slices of human pancreatic ductal adenocarcinoma (PDAC): morphological and immunohistochemical analysis with comparison to resected specimen and organoids
Jovan Todorovic, Göttingen

11:45 - 12:10 
T-cell responses in pancreatic cancer 
Magdalena Huber, Marburg

12:10 - 13:15 Lunch break

13:15 - 14:30 
Poster-Session B

14:30 - 15:15 
Chair Key Note Lecture 2: 
Tony Gutschner, Halle (Saale) / Laura Roth, Heidelberg 

Insights into Early and Advanced Pancreatic Cancer from Spatial Profiling (virtual presentation)
Anirban Maitra, New York

15:15 - 15:45 Coffee & Cake

Session 5: RNA biology meets PDAC
Chair Session 5: Stefan Hüttelmaier, Halle (Saale) / Mobina Kiani, Halle (Saale)

15:45 - 16:10
Targeting the Integrators: IGF2BPs at the Crossroads of PDAC Progression and Immune Evasion
Nadine Bley, Halle (Saale)

16:10 - 16:25
An alternative translation program underlies tumor-suppressive effects of TGF-β in early pancreatic carcinogenesis
Pit Preckwinkel, Halle (Saale)

16:25 - 16:40
KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival
Thomas Ekstrom, Stuttgart

16:40 - 17:05
LncRNAs – Promising targets in PDAC?
Roland Rad, Munich

17:30 Guided Tours through Leopoldina or Meckelsche Sammlungen (optional)

19:30 Conference Dinner (Bergschenke)

07:30 - 08:15 Pancreatic Cancer Run
Running-Guides: Jörg Kleeff and Tony Gutschner
Meeting Point: Market square/Händel monument; Distance: 5K

Session 6: Emerging topics in PDAC - Part 1
Chair Session 6 - Teil 1: Monika Hämmerle, Halle (Saale) / Uddipta Biswas, Heidelberg

09:00 - 09:25
Understanding and exploiting ARDI1A-deficiency in pancreatic cancer
Elisabeth Heßmann, Göttingen

09:25 - 09:50
Stroma is key in PDAC treatment
Corinne Bousquet, Toulouse

09:50 - 10:05
DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
Anna Brichkina, Marburg

10:05 - 10:20
Targeting transcriptional addiction to anti-senescence programs in pancreatic cancer
Adi Mackay, Göttingen

10:20 - 10:45 Coffee break

Session 6: Emerging topics in PDAC - Part 2
Chair Session 6 - Teil 2: Malte Buchholz, Marburg / Florian Döbbe, Göttingen

10:45 - 11:10
Spatial mapping of the human pancreatic duct unveils a basal and luminal cell types with distinct representation in cancer subtypes
Ilse Rooman, Brussels 

11:10 - 11:35
New insights into ADM development   
Roland Schmid, Munich

11:35 - 12:00
Genomic instability and cellular plasticity in pancreatic cancer progression
Barbara Grüner, Essen

12:00 - 12:30
Awards & Farewell incl. snacks before departure
Jonas Rosendahl, Ivonne Regel, Tony Gutschner